Not everyone in Pergamon accepted Rome’s rule.

Aristonicus, who claimed to be Attalus’ brother as well as the son of Eumenes II, an earlier king, led a revolt among the lower classes with the help of Blossius. The revolt was put down in 129 BC, and Pergamon was divided among Rome, Pontus, and Cappadocia.

Pergamon was briefly the capital of the Roman province of Asia, before the capital was transferred to Ephesus.

After a slow decline, the city was favoured by several imperial initiatives under Hadrian (117 - 138). It was granted the title of metropolis and as a result of this an ambitious building programme was carried out: massive temples, a stadium, a theatre, a huge forum and an amphitheatre were constructed. In addition, at the city limits the shrine to Asclepius (the god of healing) was expanded into a lavish spa.